The role of calcium ion in methoxamine-induced amylase release from parotid glands of euthyroid and hypothyroid rats.
نویسندگان
چکیده
The change in responsiveness to alpha-adrenergic stimulation and to calcium ions in amylase release from parotid glands of hypothyroid rats was compared with that in euthyroid rats. Calcium depletion and addition of verapamil or W-7 in the medium caused a decrease in methoxamine-induced amylase release in both eu- and hypothyroid rats. Moreover, addition of calcium ions to Ca2+-free medium markedly increased the methoxamine-induced amylase release in proportion to its concentration in hypothyroid rats. These results suggest that calcium ions play an important role in methoxamine-induced amylase release from parotid glands of hypothyroid rats as well as those of the euthyroid ones.
منابع مشابه
Amylase release from parotid glands of hypothyroid rats. II. Phosphorylation of microsomal proteins and effects of adenosine 3',5'-monophosphate and tolbutamide.
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عنوان ژورنال:
- Japanese journal of pharmacology
دوره 37 1 شماره
صفحات -
تاریخ انتشار 1985